CMT disease severity correlates with mutation-induced open conformation of histidyl-tRNA synthetase, not aminoacylation loss, in patient cells I Paper Aminoacyl-tRNA synthetases (aaRSs) are ubiquitously expressed enzymes catalyzing the charging of tRNAs with their...
A DNA-based biosensor assay for the kinetic characterization of ion-dependent aptamer folding and protein binding I Publication Therapeutic and diagnostic aptamers are nucleic acid oligomers designed to bind tightly and specifically to their target. Here, we present...
A new biosensor-based assay for aptamer-protein interaction analysis I App Note Here we show how aptamer-protein interactions can be analyzed with DNA-based biosensors. To this end, we study the salt-dependence and sequence and structure specificity of the...
Triazine-Modified 7-Deaza-2′-deoxyadenosines: Better Suited for Bioorthogonal Labeling of DNA by PCR than 2′-Deoxyuridines I Publication 6-Ethynyl-1,2,4-triazine is a small bioorthogonally reactive group we applied for fluorescent labeling of oligonucleotides by...
switchSENSE®ApplicationLibrary switchSENSE® – Biophysical Analysis with Electro-Switchable Biosurfaces I Presentation Join us for this recorded webinar presentation to learn more about dynamicBIOSENSORS’ pioneering switchSENSE® sensor platform: an...