Size + Conformation | Dynamic Biosensors

Nucleotide binding kinetics and conformational change analysis of tissue transglutaminase with switchSENSE

Nucleotide binding kinetics and conformational change analysis of tissue transglutaminase with switchSENSE I Paper Function, activity, and interactions of proteins crucially depend on their three-dimensional structure and are often regulated by effector binding and...

The trimer to monomer transition of Tumor Necrosis Factor-Alpha is a dynamic process that is significantly altered by therapeutic antibodies

The trimer to monomer transition of Tumor Necrosis Factor-Alpha is a dynamic process that is significantly altered by therapeutic antibodies I Paper The cytokine tumor necrosis factor-alpha (TNF-α) readily forms homotrimers at sub-nM concentrations to promote...

CMT disease severity correlates with mutation-induced open conformation of histidyl-tRNA synthetase, not aminoacylation loss, in patient cells I Paper

CMT disease severity correlates with mutation-induced open conformation of histidyl-tRNA synthetase, not aminoacylation loss, in patient cells I Paper Aminoacyl-tRNA synthetases (aaRSs) are ubiquitously expressed enzymes catalyzing the charging of tRNAs with their...

A DNA-based biosensor assay for the kinetic characterization of ion-dependent aptamer folding and protein binding I Publication

A DNA-based biosensor assay for the kinetic characterization of ion-dependent aptamer folding and protein binding I Publication Therapeutic and diagnostic aptamers are nucleic acid oligomers designed to bind tightly and specifically to their target. Here, we present...

A new biosensor-based assay for aptamer-protein interaction analysis I App Note

A new biosensor-based assay for aptamer-protein interaction analysis I App Note Here we show how aptamer-protein interactions can be analyzed with DNA-based biosensors. To this end, we study the salt-dependence and sequence and structure specificity of the...

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Nucleotide binding kinetics and conformational change analysis of tissue transglutaminase with switchSENSE

The trimer to monomer transition of Tumor Necrosis Factor-Alpha is a dynamic process that is significantly altered by therapeutic antibodies

CMT disease severity correlates with mutation-induced open conformation of histidyl-tRNA synthetase, not aminoacylation loss, in patient cells I Paper

A DNA-based biosensor assay for the kinetic characterization of ion-dependent aptamer folding and protein binding I Publication

A new biosensor-based assay for aptamer-protein interaction analysis I App Note

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