Nucleic Acids | Dynamic Biosensors

Nucleotide binding kinetics and conformational change analysis of tissue transglutaminase with switchSENSE

Nucleotide binding kinetics and conformational change analysis of tissue transglutaminase with switchSENSE I Paper Function, activity, and interactions of proteins crucially depend on their three-dimensional structure and are often regulated by effector binding and...

A straightforward method to conjugate antibodies to oligonucleotides – preparation, purification and their applications

A straightforward method to conjugate antibodies to oligonucleotides – preparation, purification and their applications I AppNote Antibody oligonucleotide conjugates are playing a significant role for a wide range of diagnostic and therapeutic applications....

An autoinhibitory intramolecular interaction proof-reads RNA recognition by the essential splicing factor U2AF2

An autoinhibitory intramolecular interaction proof-reads RNA recognition by the essential splicing factor U2AF2 I Paper The recognition of cis-regulatory RNA motifs in human transcripts by RNA binding proteins (RBPs) is essential for gene regulation. The molecular...

Preparation of single- and double-oligonucleotide antibody conjugates and their application for protein analytics

Preparation of single- and double-oligonucleotide antibody conjugates and their application for protein analytics I Paper Oligonucleotide-conjugated antibodies have gained importance for their use in protein diagnostics. The possibility to transfer the readout...

Site-specific covalent conjugation and purification of His-tagged proteins to DNA for switchSENSE® applications I App Note

Site-specific covalent conjugation and purification of His-tagged proteins to DNA for switchSENSE® applications I App Note In this application note, we introduce a conjugation kit for a straightforward, site-selective and covalent conjugation of His-tagged proteins...

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Nucleotide binding kinetics and conformational change analysis of tissue transglutaminase with switchSENSE

A straightforward method to conjugate antibodies to oligonucleotides – preparation, purification and their applications

An autoinhibitory intramolecular interaction proof-reads RNA recognition by the essential splicing factor U2AF2

Preparation of single- and double-oligonucleotide antibody conjugates and their application for protein analytics

Site-specific covalent conjugation and purification of His-tagged proteins to DNA for switchSENSE® applications I App Note

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