Proteins | Dynamic Biosensors

Nucleotide binding kinetics and conformational change analysis of tissue transglutaminase with switchSENSE

Nucleotide binding kinetics and conformational change analysis of tissue transglutaminase with switchSENSE I Paper Function, activity, and interactions of proteins crucially depend on their three-dimensional structure and are often regulated by effector binding and...

An autoinhibitory intramolecular interaction proof-reads RNA recognition by the essential splicing factor U2AF2

An autoinhibitory intramolecular interaction proof-reads RNA recognition by the essential splicing factor U2AF2 I Paper The recognition of cis-regulatory RNA motifs in human transcripts by RNA binding proteins (RBPs) is essential for gene regulation. The molecular...

Validation of the Slow Off-Kinetics of Sirtuin-Rearranging Ligands (SirReals) by Means of Label-Free Electrically Switchable Nanolever Technology

Validation of the Slow Off-Kinetics of Sirtuin-Rearranging Ligands (SirReals) by Means of Label-Free Electrically Switchable Nanolever Technology I Paper We have discovered the sirtuin‐rearranging ligands (SirReals) to be highly potent and selective inhibitors of...

Site-specific covalent conjugation and purification of His-tagged proteins to DNA for switchSENSE® applications I App Note

Site-specific covalent conjugation and purification of His-tagged proteins to DNA for switchSENSE® applications I App Note In this application note, we introduce a conjugation kit for a straightforward, site-selective and covalent conjugation of His-tagged proteins...

CMT disease severity correlates with mutation-induced open conformation of histidyl-tRNA synthetase, not aminoacylation loss, in patient cells I Paper

CMT disease severity correlates with mutation-induced open conformation of histidyl-tRNA synthetase, not aminoacylation loss, in patient cells I Paper Aminoacyl-tRNA synthetases (aaRSs) are ubiquitously expressed enzymes catalyzing the charging of tRNAs with their...

« Older Entries

Nucleotide binding kinetics and conformational change analysis of tissue transglutaminase with switchSENSE

An autoinhibitory intramolecular interaction proof-reads RNA recognition by the essential splicing factor U2AF2

Validation of the Slow Off-Kinetics of Sirtuin-Rearranging Ligands (SirReals) by Means of Label-Free Electrically Switchable Nanolever Technology

Site-specific covalent conjugation and purification of His-tagged proteins to DNA for switchSENSE® applications I App Note

CMT disease severity correlates with mutation-induced open conformation of histidyl-tRNA synthetase, not aminoacylation loss, in patient cells I Paper

CONTACT US! WE WILL GET IN TOUCH WITH YOU SHORTLY.

CONTACT US!
WE WILL GET IN TOUCH WITH YOU SHORTLY.